Disseminated sclerosis is numbered to the group of demyelinating diseases of nervous system and characterized by the young contingent of patients, peculiar epidemiology and pathomorphology, difficulty in diagnosis and treatment.
The essence of disease is not limited by the formation of sclerotic plaques. The pathological process also involves immune system, different sides of metabolism, structures of vegetative nervous system (V.A.Karlov, 1990: E.I.Gusev et al., 1997; B.T.Haidarov, 1998).
According to most of the investigators devoted to this problem, disseminated sclerosis is a virus-induced disease. The leading role belongs to measles virus. The genetical determination of this disease is proven.
The complicacy of polysystemic, multi-level disturbances developed in this disease allows to determine some sanogenetic targets for efficient use of ozone therapy:
1.immunocorrection with accent on the cellular link of immunity;
2."leveling" of genetically determined and secondary developed disturbances of intracellular neurons' metabolism;
3.stabilization of myelin as biological membrane;
4.normalization of biochemical parameters and gas composition of blood;
5.restoration of "trophic control" on the part of vegetative nervous system.
The clinical investigation included 67 patients with disseminated sclerosis and 15 volunteers. Age of the investigated patients ranged from 19 to 49 years. Among the patients there were 39 women and 28 men. Average duration of disease was 3,8 years.
All the investigated patients were divided into 4 groups: 2 main (test) and 2 control (placebo). The treatment of patients of the 1st main group (n=22) along with standard therapeutic complex (prednisolon 30-60 mg/24 hrs, vitamins B, C, E, phytin, curantyl, ATP, T-activin, nootropil) included intravenous infusions of ozonated saline solution with ozone concentration. The patients of the 2nd main group (n=23) along with the above-mentioned standard treatment received ozone therapy in the form of intravenous infusions of ozonated saline solution in combination with per os intake of ozonated suspension of enterosorbent "Ensoral" in distilled water. This schema of treatment was based on the evidence about the efficiency of enterosorbents for patients with disseminated sclerosis as well as on the assumption about possible mutual potentiation of detoxication and immunomodulating effects of ozone and enterosorbents used in combination. And the great area of sorbing surface of "Ensoral" with structure C - C - C - C was considered a prerequisite for a certain "depot" of ozone within the whole gastroenteric tract. The selected ozone concentration is usually used for enteral methods of ozone therapy.
The received results have shown that the second variant of multimodality therapy has proved to be the most effective in the treatment of patients with disseminated sclerosis. The use of the above-mentioned treatment schema facilitated a decrease in the resistance to the performed therapy though the decrease in non-responders; prevention of increased deficit of T-lymphocytes (particularly T-suppressors) connected with the use of glucocorticoide hormones (parallel to regression of B-lymphocytes); normalization of vegetative tone in the cardiovascular system; increase in the transmission rate of nervous impulses through peripheral nerves.